Integrating optical sensing into lab-on-a-chip systems

Polymer multilevel lab-on-chip systems for electrochemical sensing

Lab-on-a-chip with integrated optical transducers.

Taking the next step from individual functional components to higher integrated devices, we present a feasibility study of a lab-on-a-chip system with five different components monolithically integrated on one substrate. These five components represent three main domains of microchip technology: optics, fluidics and electronics. In particular, this device includes an on-chip optically pumped li...

Lab-on-chip systems for integrated bioanalyses

Biomolecular detection systems based on microfluidics are often called lab-on-chip systems. To fully benefit from the miniaturization resulting from microfluidics, one aims to develop 'from sample-to-answer' analytical systems, in which the input is a raw or minimally processed biological, food/feed or environmental sample and the output is a quantitative or qualitative assessment of one or mor...

Optical Multiplexing of Multiple Fluorescence Sensors for Compact Lab-on-a-chip Systems

Frequency domain multiplexing combined with optical waveguides provides a low cost and efficient approach to optical detection in arrayed microfluidic chips by eliminating detection components and improving acquisition time. A waveguide test chip fabricated in PDMS demonstrates 4:1 multiplexing in the readout by utilizing multilayer waveguides.

Optical sensing for on-chip digital microfluidics

A digital microfluidic architecture is introduced for micron-scale localized fluid actuation and in in-situ optical sensing. Contemporary device integration challenges related to localization and device scalability are overcome through the introduction of a bi-layered digital microfluidic multiplexer. Trinary inputs are applied through differential combinations of voltage signals between upper ...